Assay Detail
Functional
CHEMBL4738310
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS stimulated TNF-alpha production in mouse RAW264.7 macrophages preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by EIA
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, biological evaluation, and docking studies of novel (imidazol-5-yl)pyrimidine-based derivatives as dual BRAF/p38α inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.16 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4793723 | — | — | 1 | 7.02 |
| CHEMBL403183 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4793723 | — | IC50 | = | 96.3 | nM | 7.02 |
| CHEMBL403183 | — | IC50 | = | 5180.0 | nM | 5.29 |