Assay Detail
Binding
CHEMBL4738318
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BRAF V600E mutant (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, biological evaluation, and docking studies of novel (imidazol-5-yl)pyrimidine-based derivatives as dual BRAF/p38α inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.78 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2028663 | DABRAFENIB | 4.0 | 1 | 9.15 |
| CHEMBL3301612 | ENCORAFENIB | 4.0 | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2028663 | DABRAFENIB | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3301612 | ENCORAFENIB | IC50 | = | 4.0 | nM | 8.40 |