Assay Detail
Functional
CHEMBL4738396
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Antimalarial activity against asexual blood stage of Mefloquine-resistant Plasmodium falciparum W2mef assessed as reduction in cell viability after 72 hrs by EtBr staining based flow cytometric analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure activity refinement of phenylsulfonyl piperazines as antimalarials that block erythrocytic invasion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.92 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4761334 | — | — | 1 | 7.40 |
| CHEMBL4747247 | — | — | 1 | 7.22 |
| CHEMBL4744072 | — | — | 1 | 7.05 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.60 |
| CHEMBL4783405 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4761334 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4747247 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4744072 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4783405 | — | EC50 | = | 490.0 | nM | 6.31 |