Assay Detail
Functional
CHEMBL4738680
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against multidrug-resistant human MES-SA/Dx5 cells assessed as reduction in cell viability incubated for 72 hrs by prestoblue dye based assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MES-SA/Dx5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Combretastatin A-4 sulfur-containing heterocyclic derivatives: Synthesis, antiproliferative activities and molecular docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.20 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.52 |
| CHEMBL2205254 | — | — | 1 | 7.72 |
| CHEMBL3747373 | — | — | 1 | 7.57 |
| CHEMBL3747782 | — | — | 1 | 7.12 |
| CHEMBL3746505 | — | — | 1 | 6.82 |
| CHEMBL3747237 | — | — | 1 | 6.54 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 6.12 |
| CHEMBL4780261 | — | — | 1 | - |
| CHEMBL4743915 | — | — | 1 | - |
| CHEMBL4753697 | — | — | 1 | - |
| CHEMBL4785381 | — | — | 1 | - |
| CHEMBL3746113 | — | — | 1 | - |
| CHEMBL121129 | — | — | 1 | - |
| CHEMBL4762961 | — | — | 1 | - |
| CHEMBL3746053 | — | — | 1 | - |
| CHEMBL3747697 | — | — | 1 | - |
| CHEMBL3747147 | — | — | 1 | - |
| CHEMBL4793584 | — | — | 1 | - |
| CHEMBL4764148 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2205254 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3747373 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3747782 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL3746505 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3747237 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL107 | COLCHICINE | IC50 | = | 757.0 | nM | 6.12 |
| CHEMBL4780261 | — | IC50 | - | — | - | |
| CHEMBL4743915 | — | IC50 | - | — | - | |
| CHEMBL4753697 | — | IC50 | - | — | - | |
| CHEMBL4785381 | — | IC50 | - | — | - | |
| CHEMBL3746113 | — | IC50 | - | — | - | |
| CHEMBL121129 | — | IC50 | - | — | - | |
| CHEMBL4762961 | — | IC50 | - | — | - | |
| CHEMBL3746053 | — | IC50 | - | — | - | |
| CHEMBL3747697 | — | IC50 | - | — | - | |
| CHEMBL3747147 | — | IC50 | - | — | - | |
| CHEMBL4793584 | — | IC50 | - | — | - | |
| CHEMBL4764148 | — | IC50 | - | — | - |