Assay Detail
Functional
CHEMBL4738683
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MIA PaCa-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Combretastatin A-4 sulfur-containing heterocyclic derivatives: Synthesis, antiproliferative activities and molecular docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.75 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.68 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.21 |
| CHEMBL2205254 | — | — | 1 | 8.11 |
| CHEMBL3747373 | — | — | 1 | 7.85 |
| CHEMBL4785381 | — | — | 1 | 6.92 |
| CHEMBL4780261 | — | — | 1 | 6.70 |
| CHEMBL3747237 | — | — | 1 | - |
| CHEMBL4743915 | — | — | 1 | - |
| CHEMBL4753697 | — | — | 1 | - |
| CHEMBL3746113 | — | — | 1 | - |
| CHEMBL121129 | — | — | 1 | - |
| CHEMBL3747782 | — | — | 1 | - |
| CHEMBL4762961 | — | — | 1 | - |
| CHEMBL3746053 | — | — | 1 | - |
| CHEMBL3747697 | — | — | 1 | - |
| CHEMBL3747147 | — | — | 1 | - |
| CHEMBL4793584 | — | — | 1 | - |
| CHEMBL4764148 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL107 | COLCHICINE | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL2205254 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL3747373 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4785381 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4780261 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3747237 | — | IC50 | - | — | - | |
| CHEMBL4743915 | — | IC50 | - | — | - | |
| CHEMBL4753697 | — | IC50 | - | — | - | |
| CHEMBL3746113 | — | IC50 | - | — | - | |
| CHEMBL121129 | — | IC50 | - | — | - | |
| CHEMBL3747782 | — | IC50 | - | — | - | |
| CHEMBL4762961 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3746053 | — | IC50 | - | — | - | |
| CHEMBL3747697 | — | IC50 | - | — | - | |
| CHEMBL3747147 | — | IC50 | - | — | - | |
| CHEMBL4793584 | — | IC50 | - | — | - | |
| CHEMBL4764148 | — | IC50 | - | — | - |