Assay Detail
Functional
CHEMBL4738962
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Antimalarial activity against artemisinin-sensitive Plasmodium falciparum F32-TEM by SYBR green dye based fluorescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel molecule combinations and corresponding hybrids targeting artemisinin-resistant Plasmodium falciparum parasites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.13 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4754983 | — | — | 1 | 9.22 |
| CHEMBL4786319 | — | — | 1 | 9.22 |
| CHEMBL4749050 | — | — | 1 | 8.96 |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 8.68 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.75 |
| CHEMBL467584 | — | — | 1 | 7.38 |
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 7.06 |
| CHEMBL4780455 | — | — | 1 | 6.77 |
| CHEMBL849 | TRICLOSAN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4754983 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4786319 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4749050 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL467584 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL172 | (S,R)-MEFLOQUINE | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL4780455 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL849 | TRICLOSAN | IC50 | = | 510000.0 | nM | - |