Assay Detail
Functional
CHEMBL4738989
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Cytotoxicity against human SMMC-7721 cells assessed as cell viability after 24 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SMMC-7721 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of artemisinin-piperazine-furan ether hybrids and evaluation of in vitro cytotoxic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.36 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4752322 | — | — | 1 | 6.58 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 6.57 |
| CHEMBL4744767 | — | — | 1 | 6.54 |
| CHEMBL4786076 | — | — | 1 | 6.41 |
| CHEMBL4796594 | — | — | 1 | 6.37 |
| CHEMBL4758529 | — | — | 1 | 6.32 |
| CHEMBL4741804 | — | — | 1 | 6.28 |
| CHEMBL4786680 | — | — | 1 | 6.25 |
| CHEMBL4749733 | — | — | 1 | 6.24 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 6.20 |
| CHEMBL511326 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4752322 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4744767 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4786076 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4796594 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4758529 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4741804 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4786680 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4749733 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL511326 | — | IC50 | = | 700.0 | nM | 6.16 |