Assay Detail
Functional
CHEMBL4739391
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of two novel thiophene analogues as inducers of autophagy mediated cell death in breast cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.09 | 5.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4796608 | — | — | 1 | 5.73 |
| CHEMBL52388 | — | — | 1 | 5.71 |
| CHEMBL187266 | TANSHINONE IIA | — | 1 | 5.11 |
| CHEMBL363535 | TANSHINONE I | — | 1 | 5.10 |
| CHEMBL4760045 | — | — | 1 | 5.10 |
| CHEMBL4746900 | — | — | 1 | 4.89 |
| CHEMBL4785489 | — | — | 1 | 4.84 |
| CHEMBL4754267 | — | — | 1 | 4.84 |
| CHEMBL4764362 | — | — | 1 | 4.80 |
| CHEMBL4776098 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4796608 | — | IC50 | = | 1856.5 | nM | 5.73 |
| CHEMBL52388 | — | IC50 | = | 1945.0 | nM | 5.71 |
| CHEMBL187266 | TANSHINONE IIA | IC50 | = | 7793.5 | nM | 5.11 |
| CHEMBL363535 | TANSHINONE I | IC50 | = | 7927.0 | nM | 5.10 |
| CHEMBL4760045 | — | IC50 | = | 8020.0 | nM | 5.10 |
| CHEMBL4746900 | — | IC50 | = | 12786.5 | nM | 4.89 |
| CHEMBL4785489 | — | IC50 | = | 14411.0 | nM | 4.84 |
| CHEMBL4754267 | — | IC50 | = | 14566.0 | nM | 4.84 |
| CHEMBL4764362 | — | IC50 | = | 15762.5 | nM | 4.80 |
| CHEMBL4776098 | — | IC50 | = | 17522.5 | nM | 4.76 |