Assay Detail
Functional
CHEMBL4739392
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 24 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of two novel thiophene analogues as inducers of autophagy mediated cell death in breast cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.01 | 5.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52388 | — | — | 1 | 5.59 |
| CHEMBL4796608 | — | — | 1 | 5.53 |
| CHEMBL4760045 | — | — | 1 | 5.22 |
| CHEMBL187266 | TANSHINONE IIA | — | 1 | 5.11 |
| CHEMBL363535 | TANSHINONE I | — | 1 | 5.10 |
| CHEMBL4746900 | — | — | 1 | 4.81 |
| CHEMBL4764362 | — | — | 1 | 4.76 |
| CHEMBL4754267 | — | — | 1 | 4.69 |
| CHEMBL4785489 | — | — | 1 | 4.68 |
| CHEMBL4776098 | — | — | 1 | 4.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52388 | — | IC50 | = | 2595.0 | nM | 5.59 |
| CHEMBL4796608 | — | IC50 | = | 2955.0 | nM | 5.53 |
| CHEMBL4760045 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL187266 | TANSHINONE IIA | IC50 | = | 7695.0 | nM | 5.11 |
| CHEMBL363535 | TANSHINONE I | IC50 | = | 7962.0 | nM | 5.10 |
| CHEMBL4746900 | — | IC50 | = | 15610.0 | nM | 4.81 |
| CHEMBL4764362 | — | IC50 | = | 17450.0 | nM | 4.76 |
| CHEMBL4754267 | — | IC50 | = | 20565.0 | nM | 4.69 |
| CHEMBL4785489 | — | IC50 | = | 20875.0 | nM | 4.68 |
| CHEMBL4776098 | — | IC50 | = | 23428.5 | nM | 4.63 |