Assay Detail
Binding
CHEMBL4739784
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Inhibition of CDK7 (unknown origin)
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of cyclin-dependent kinases
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.23 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4756353 | — | — | 1 | 7.27 |
| CHEMBL4753717 | — | — | 1 | 7.08 |
| CHEMBL4644893 | — | — | 1 | 7.00 |
| CHEMBL4777844 | — | — | 1 | 6.88 |
| CHEMBL4744850 | — | — | 1 | 6.80 |
| CHEMBL4756935 | — | — | 1 | 6.65 |
| CHEMBL4786429 | — | — | 1 | 6.65 |
| CHEMBL4758168 | — | — | 1 | 6.64 |
| CHEMBL4788136 | — | — | 1 | 6.62 |
| CHEMBL4761637 | — | — | 1 | 6.51 |
| CHEMBL4781539 | — | — | 1 | 6.46 |
| CHEMBL4744627 | — | — | 1 | 6.35 |
| CHEMBL4641226 | — | — | 1 | 6.34 |
| CHEMBL4752238 | — | — | 1 | 6.30 |
| CHEMBL4752989 | — | — | 1 | 6.25 |
| CHEMBL4797409 | — | — | 1 | 5.97 |
| CHEMBL4643057 | — | — | 1 | 5.94 |
| CHEMBL4788401 | — | — | 1 | 5.89 |
| CHEMBL4789890 | — | — | 1 | 5.54 |
| CHEMBL4753350 | — | — | 1 | 5.47 |
| CHEMBL4761001 | — | — | 1 | 5.30 |
| CHEMBL4793573 | — | — | 1 | 5.26 |
| CHEMBL4776271 | — | — | 1 | 5.21 |
| CHEMBL4781334 | — | — | 1 | 5.05 |
| CHEMBL4789917 | — | — | 1 | - |
| CHEMBL4797288 | — | — | 1 | - |
| CHEMBL4643754 | — | — | 1 | - |
| CHEMBL4777761 | — | — | 1 | - |
| CHEMBL4786324 | — | — | 1 | - |
| CHEMBL4764719 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4756353 | — | IC50 | = | 53.6 | nM | 7.27 |
| CHEMBL4753717 | — | IC50 | = | 82.5 | nM | 7.08 |
| CHEMBL4644893 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL4777844 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL4744850 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL4756935 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL4786429 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL4758168 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4788136 | — | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL4761637 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL4781539 | — | IC50 | = | 346.0 | nM | 6.46 |
| CHEMBL4744627 | — | IC50 | = | 447.0 | nM | 6.35 |
| CHEMBL4641226 | — | IC50 | = | 457.0 | nM | 6.34 |
| CHEMBL4752238 | — | IC50 | = | 498.0 | nM | 6.30 |
| CHEMBL4752989 | — | IC50 | = | 556.0 | nM | 6.25 |
| CHEMBL4797409 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4643057 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL4788401 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL4789890 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL4753350 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4761001 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4793573 | — | IC50 | = | 5550.0 | nM | 5.26 |
| CHEMBL4776271 | — | IC50 | = | 6170.0 | nM | 5.21 |
| CHEMBL4781334 | — | IC50 | = | 8870.0 | nM | 5.05 |
| CHEMBL4790868 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4749580 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4763994 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4743840 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4746993 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4763202 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4794338 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4764719 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4786324 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4777761 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4643754 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4797288 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4789917 | — | IC50 | > | 1000.0 | nM | - |