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Assay Detail

CHEMBL4742484

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Binding
Inhibition of CDK2/Cyclin E (unknown origin) using 5-FAM-CDK7tide substrate incubated for 35 mins
ChEMBL ↗
277
Total Activities
277
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

Cyclin-dependent kinase 2/cyclin E1 (CHEMBL1907605) ↗
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Inhibitors of cyclin-dependent kinase 7 (cdk7)
(2019)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 277 6.76 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4781192 — — 1 7.70
CHEMBL4799523 — — 1 7.70
CHEMBL4790249 — — 1 7.70
CHEMBL4794359 — — 1 7.70
CHEMBL4797879 — — 1 7.70
CHEMBL4781938 — — 1 7.70
CHEMBL4788695 — — 1 7.70
CHEMBL4785708 — — 1 7.70
CHEMBL4785816 — — 1 7.70
CHEMBL4791134 — — 1 6.70
CHEMBL4783735 — — 1 6.70
CHEMBL4778981 — — 1 6.70
CHEMBL4799405 — — 1 6.70
CHEMBL4790771 — — 1 6.70
CHEMBL4796480 — — 1 6.70
CHEMBL4799805 — — 1 6.70
CHEMBL4786864 — — 1 6.70
CHEMBL4796559 — — 1 6.70
CHEMBL4792679 — — 1 6.70
CHEMBL4796032 — — 1 6.70
CHEMBL4789861 — — 1 6.70
CHEMBL4794403 — — 1 6.70
CHEMBL4793244 — — 1 6.70
CHEMBL4800535 — — 1 6.70
CHEMBL4788933 — — 1 6.70
CHEMBL4781069 — — 1 6.70
CHEMBL4797244 — — 1 6.70
CHEMBL4474655 — — 1 6.70
CHEMBL4786320 — — 1 6.70
CHEMBL4533453 — — 1 6.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4785708 — IC50 = 20.0 nM 7.70
CHEMBL4785816 — IC50 = 20.0 nM 7.70
CHEMBL4781938 — IC50 = 20.0 nM 7.70
CHEMBL4799523 — IC50 = 20.0 nM 7.70
CHEMBL4797879 — IC50 = 20.0 nM 7.70
CHEMBL4794359 — IC50 = 20.0 nM 7.70
CHEMBL4790249 — IC50 = 20.0 nM 7.70
CHEMBL4788695 — IC50 = 20.0 nM 7.70
CHEMBL4781192 — IC50 = 20.0 nM 7.70
CHEMBL4786555 — IC50 = 200.0 nM 6.70
CHEMBL4776647 — IC50 = 200.0 nM 6.70
CHEMBL4786832 — IC50 = 200.0 nM 6.70
CHEMBL4777468 — IC50 = 200.0 nM 6.70
CHEMBL4778392 — IC50 = 200.0 nM 6.70
CHEMBL4789351 — IC50 = 200.0 nM 6.70
CHEMBL4798558 — IC50 = 200.0 nM 6.70
CHEMBL4784042 — IC50 = 200.0 nM 6.70
CHEMBL4781253 — IC50 = 200.0 nM 6.70
CHEMBL4792848 — IC50 = 200.0 nM 6.70
CHEMBL4787155 — IC50 = 200.0 nM 6.70
CHEMBL4800231 — IC50 = 200.0 nM 6.70
CHEMBL4792734 — IC50 = 200.0 nM 6.70
CHEMBL4795900 — IC50 = 200.0 nM 6.70
CHEMBL4533453 — IC50 = 200.0 nM 6.70
CHEMBL4799169 — IC50 = 200.0 nM 6.70
CHEMBL4779834 — IC50 = 200.0 nM 6.70
CHEMBL4792784 — IC50 = 200.0 nM 6.70
CHEMBL4786543 — IC50 = 200.0 nM 6.70
CHEMBL4797486 — IC50 = 200.0 nM 6.70
CHEMBL4781175 — IC50 = 200.0 nM 6.70
CHEMBL4790204 — IC50 = 200.0 nM 6.70
CHEMBL4784288 — IC50 = 200.0 nM 6.70
CHEMBL4787887 — IC50 = 200.0 nM 6.70
CHEMBL4778825 — IC50 = 200.0 nM 6.70
CHEMBL4780149 — IC50 = 200.0 nM 6.70
CHEMBL4783758 — IC50 = 200.0 nM 6.70
CHEMBL4793351 — IC50 = 200.0 nM 6.70
CHEMBL4783495 — IC50 = 200.0 nM 6.70
CHEMBL4786400 — IC50 = 200.0 nM 6.70
CHEMBL4778885 — IC50 = 200.0 nM 6.70
CHEMBL4788386 — IC50 = 200.0 nM 6.70
CHEMBL4797260 — IC50 = 200.0 nM 6.70
CHEMBL4776640 — IC50 = 200.0 nM 6.70
CHEMBL4788795 — IC50 = 200.0 nM 6.70
CHEMBL4788987 — IC50 = 200.0 nM 6.70
CHEMBL4776523 — IC50 = 200.0 nM 6.70
CHEMBL4796263 — IC50 = 200.0 nM 6.70
CHEMBL4799670 — IC50 = 200.0 nM 6.70
CHEMBL4782979 — IC50 = 200.0 nM 6.70
CHEMBL4793430 — IC50 = 200.0 nM 6.70