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Assay Detail

CHEMBL4742485

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of CDK12 (686 to 1082 residues) /Cyclin K (unknown origin) using 5-FAM-CDK9tide peptide substrate incubated for 3 hrs
ChEMBL ↗
277
Total Activities
277
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

CDK12/Cyclin K (CHEMBL4106169) ↗
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Inhibitors of cyclin-dependent kinase 7 (cdk7)
(2019)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 277 6.79 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4797244 — — 1 7.70
CHEMBL4792681 — — 1 7.70
CHEMBL4790249 — — 1 7.70
CHEMBL4786555 — — 1 7.70
CHEMBL4790463 — — 1 7.70
CHEMBL4797879 — — 1 7.70
CHEMBL4781938 — — 1 7.70
CHEMBL4776427 — — 1 7.70
CHEMBL4776998 — — 1 7.70
CHEMBL4793000 — — 1 7.70
CHEMBL4799523 — — 1 7.70
CHEMBL4799805 — — 1 7.70
CHEMBL4796559 — — 1 7.70
CHEMBL4789861 — — 1 7.70
CHEMBL4794403 — — 1 7.70
CHEMBL4800535 — — 1 7.70
CHEMBL4781069 — — 1 7.70
CHEMBL4474655 — — 1 7.70
CHEMBL4785816 — — 1 7.70
CHEMBL4782476 — — 1 6.70
CHEMBL4790718 — — 1 6.70
CHEMBL4792679 — — 1 6.70
CHEMBL4796032 — — 1 6.70
CHEMBL4777842 — — 1 6.70
CHEMBL4793244 — — 1 6.70
CHEMBL4788933 — — 1 6.70
CHEMBL4783125 — — 1 6.70
CHEMBL4800180 — — 1 6.70
CHEMBL4786320 — — 1 6.70
CHEMBL4533453 — — 1 6.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4797244 — IC50 = 20.0 nM 7.70
CHEMBL4474655 — IC50 = 20.0 nM 7.70
CHEMBL4790463 — IC50 = 20.0 nM 7.70
CHEMBL4799523 — IC50 = 20.0 nM 7.70
CHEMBL4785816 — IC50 = 20.0 nM 7.70
CHEMBL4797879 — IC50 = 20.0 nM 7.70
CHEMBL4799805 — IC50 = 20.0 nM 7.70
CHEMBL4790249 — IC50 = 20.0 nM 7.70
CHEMBL4781938 — IC50 = 20.0 nM 7.70
CHEMBL4796559 — IC50 = 20.0 nM 7.70
CHEMBL4786555 — IC50 = 20.0 nM 7.70
CHEMBL4793000 — IC50 = 20.0 nM 7.70
CHEMBL4789861 — IC50 = 20.0 nM 7.70
CHEMBL4794403 — IC50 = 20.0 nM 7.70
CHEMBL4800535 — IC50 = 20.0 nM 7.70
CHEMBL4781069 — IC50 = 20.0 nM 7.70
CHEMBL4776998 — IC50 = 20.0 nM 7.70
CHEMBL4776427 — IC50 = 20.0 nM 7.70
CHEMBL4792681 — IC50 = 20.0 nM 7.70
CHEMBL4782690 — IC50 = 200.0 nM 6.70
CHEMBL4794831 — IC50 = 200.0 nM 6.70
CHEMBL4796874 — IC50 = 200.0 nM 6.70
CHEMBL4790773 — IC50 = 200.0 nM 6.70
CHEMBL4797772 — IC50 = 200.0 nM 6.70
CHEMBL4793690 — IC50 = 200.0 nM 6.70
CHEMBL4790204 — IC50 = 200.0 nM 6.70
CHEMBL4787887 — IC50 = 200.0 nM 6.70
CHEMBL4780093 — IC50 = 200.0 nM 6.70
CHEMBL4790437 — IC50 = 200.0 nM 6.70
CHEMBL4793430 — IC50 = 200.0 nM 6.70
CHEMBL4782979 — IC50 = 200.0 nM 6.70
CHEMBL4776523 — IC50 = 200.0 nM 6.70
CHEMBL4788987 — IC50 = 200.0 nM 6.70
CHEMBL4800597 — IC50 = 200.0 nM 6.70
CHEMBL4790065 — IC50 = 200.0 nM 6.70
CHEMBL4793416 — IC50 = 200.0 nM 6.70
CHEMBL4779829 — IC50 = 200.0 nM 6.70
CHEMBL4800436 — IC50 = 200.0 nM 6.70
CHEMBL4777021 — IC50 = 200.0 nM 6.70
CHEMBL4795588 — IC50 = 200.0 nM 6.70
CHEMBL4792632 — IC50 = 200.0 nM 6.70
CHEMBL4796791 — IC50 = 200.0 nM 6.70
CHEMBL4800364 — IC50 = 200.0 nM 6.70
CHEMBL4779846 — IC50 = 200.0 nM 6.70
CHEMBL4777487 — IC50 = 200.0 nM 6.70
CHEMBL4785594 — IC50 = 200.0 nM 6.70
CHEMBL4778193 — IC50 = 200.0 nM 6.70
CHEMBL4788430 — IC50 = 200.0 nM 6.70
CHEMBL4791188 — IC50 = 200.0 nM 6.70
CHEMBL4783495 — IC50 = 200.0 nM 6.70