Assay Detail
Binding
CHEMBL4742549
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Binding affinity to DNA-tagged CDK-12 expressed in HEK293 cells (unknown origin) by qPCR analysis
25
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Substituted Pyrazole Derivatives As Selective CDK12/13 Inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 25 | 7.60 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4781207 | — | — | 3 | 7.60 |
| CHEMBL4781668 | — | — | 3 | 7.60 |
| CHEMBL4779066 | — | — | 2 | 7.60 |
| CHEMBL4779633 | — | — | 1 | 7.60 |
| CHEMBL4800324 | — | — | 1 | 7.60 |
| CHEMBL4778361 | — | — | 3 | 7.60 |
| CHEMBL4778214 | — | — | 1 | 7.60 |
| CHEMBL4777358 | — | — | 1 | 7.60 |
| CHEMBL4788447 | — | — | 1 | - |
| CHEMBL4786663 | — | — | 1 | - |
| CHEMBL4781396 | — | — | 1 | - |
| CHEMBL4799698 | — | — | 1 | - |
| CHEMBL4788085 | — | — | 1 | - |
| CHEMBL4787409 | — | — | 1 | - |
| CHEMBL4785443 | — | — | 1 | - |
| CHEMBL4790705 | — | — | 1 | - |
| CHEMBL4800122 | — | — | 1 | - |
| CHEMBL4790458 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4778214 | — | Kd | = | 25.0 | nM | 7.60 |
| CHEMBL4781207 | — | Kd | = | 25.0 | nM | 7.60 |
| CHEMBL4778361 | — | Kd | = | 25.0 | nM | 7.60 |
| CHEMBL4800324 | — | Kd | = | 25.0 | nM | 7.60 |
| CHEMBL4779633 | — | Kd | = | 25.0 | nM | 7.60 |
| CHEMBL4779066 | — | Kd | = | 25.0 | nM | 7.60 |
| CHEMBL4781668 | — | Kd | = | 25.0 | nM | 7.60 |
| CHEMBL4777358 | — | Kd | = | 25.0 | nM | 7.60 |
| CHEMBL4799698 | — | Kd | > | 100.0 | nM | - |
| CHEMBL4778361 | — | Kd | < | 25.0 | nM | - |
| CHEMBL4778361 | — | Kd | < | 25.0 | nM | - |
| CHEMBL4790458 | — | Kd | > | 100.0 | nM | - |
| CHEMBL4779066 | — | Kd | < | 25.0 | nM | - |
| CHEMBL4800122 | — | Kd | < | 25.0 | nM | - |
| CHEMBL4790705 | — | Kd | < | 25.0 | nM | - |
| CHEMBL4785443 | — | Kd | < | 25.0 | nM | - |
| CHEMBL4787409 | — | Kd | < | 25.0 | nM | - |
| CHEMBL4788085 | — | Kd | < | 25.0 | nM | - |
| CHEMBL4781668 | — | Kd | > | 100.0 | nM | - |
| CHEMBL4781668 | — | Kd | > | 100.0 | nM | - |
| CHEMBL4781396 | — | Kd | < | 25.0 | nM | - |
| CHEMBL4786663 | — | Kd | < | 25.0 | nM | - |
| CHEMBL4788447 | — | Kd | < | 25.0 | nM | - |
| CHEMBL4781207 | — | Kd | < | 25.0 | nM | - |
| CHEMBL4781207 | — | Kd | < | 25.0 | nM | - |