Assay Detail
Binding
CHEMBL4765712
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Inhibition of GAL4 fused TrkB (unknown origin) expressed in MG87 cells transfected with pFA2-Elk plasmid and pFR-luciferase plasmid measured for 18 hrs by luciferase reporter gene assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MG87 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Indole-like Trk receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.07 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104519 | — | — | 1 | 7.39 |
| CHEMBL104333 | — | — | 1 | 6.96 |
| CHEMBL322153 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104519 | — | IC50 | = | 41.07 | nM | 7.39 |
| CHEMBL104333 | — | IC50 | = | 110.95 | nM | 6.96 |
| CHEMBL322153 | — | IC50 | = | 141.83 | nM | 6.85 |