Assay Detail
Functional
CHEMBL4765820
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Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and Biological Evaluation of N-[2-(4-Hydroxyphenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide (ABT-751) Tricyclic Analogues as Antimitotic and Antivascular Agents with Potent in Vivo Antitumor Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.17 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4794337 | — | — | 1 | 8.00 |
| CHEMBL4785331 | — | — | 1 | 7.38 |
| CHEMBL4777687 | — | — | 1 | 6.80 |
| CHEMBL4779335 | — | — | 1 | 6.70 |
| CHEMBL20684 | ABT-751 | 2.0 | 1 | 6.68 |
| CHEMBL4789264 | — | — | 1 | 6.12 |
| CHEMBL4778834 | — | — | 1 | 5.39 |
| CHEMBL4799616 | — | — | 1 | 5.33 |
| CHEMBL4776691 | — | — | 1 | 5.24 |
| CHEMBL4784977 | — | — | 1 | 5.11 |
| CHEMBL4792371 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4794337 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4785331 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4777687 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4779335 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL20684 | ABT-751 | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4789264 | — | IC50 | = | 766.0 | nM | 6.12 |
| CHEMBL4778834 | — | IC50 | = | 4050.0 | nM | 5.39 |
| CHEMBL4799616 | — | IC50 | = | 4730.0 | nM | 5.33 |
| CHEMBL4776691 | — | IC50 | = | 5730.0 | nM | 5.24 |
| CHEMBL4784977 | — | IC50 | = | 7770.0 | nM | 5.11 |
| CHEMBL4792371 | — | IC50 | = | 7780.0 | nM | 5.11 |