Assay Detail
Functional
CHEMBL4766121
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-435 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
From Lead to Drug Candidate: Optimization of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Derivatives as Agents for the Treatment of Triple Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 55 | 6.91 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4789115 | — | — | 1 | 8.40 |
| CHEMBL3426225 | — | — | 1 | 8.30 |
| CHEMBL4778099 | — | — | 1 | 8.15 |
| CHEMBL4798527 | — | — | 1 | 8.10 |
| CHEMBL4794299 | — | — | 1 | 8.00 |
| CHEMBL4780898 | — | — | 1 | 8.00 |
| CHEMBL4797609 | — | — | 1 | 7.92 |
| CHEMBL4799744 | — | — | 1 | 7.80 |
| CHEMBL4793359 | — | — | 1 | 7.70 |
| CHEMBL4782399 | — | — | 1 | 7.70 |
| CHEMBL4793811 | — | — | 1 | 7.57 |
| CHEMBL4786922 | — | — | 1 | 7.57 |
| CHEMBL4783566 | — | — | 1 | 7.52 |
| CHEMBL4798578 | — | — | 1 | 7.43 |
| CHEMBL4794531 | — | — | 1 | 7.40 |
| CHEMBL4799987 | — | — | 1 | 7.36 |
| CHEMBL4784062 | — | — | 1 | 7.26 |
| CHEMBL4794638 | — | — | 1 | 7.21 |
| CHEMBL4787198 | — | — | 1 | 7.20 |
| CHEMBL4792369 | — | — | 1 | 7.19 |
| CHEMBL4799351 | — | — | 1 | 7.14 |
| CHEMBL4787515 | — | — | 1 | 7.10 |
| CHEMBL4794088 | — | — | 1 | 7.10 |
| CHEMBL4791669 | — | — | 1 | 7.09 |
| CHEMBL4790050 | — | — | 1 | 7.05 |
| CHEMBL4780429 | — | — | 1 | 7.03 |
| CHEMBL4788755 | — | — | 1 | 7.03 |
| CHEMBL4793737 | — | — | 1 | 6.96 |
| CHEMBL4780200 | — | — | 1 | 6.94 |
| CHEMBL4781104 | — | — | 1 | 6.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4789115 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3426225 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4778099 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4798527 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4794299 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4780898 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4797609 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4799744 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4793359 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4782399 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4793811 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4786922 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4783566 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4798578 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4794531 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4799987 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4784062 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4794638 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4787198 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4792369 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4799351 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4787515 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4794088 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4791669 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4790050 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4780429 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4788755 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL4793737 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL4780200 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL4781104 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL4790093 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL4791964 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL4788055 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4794967 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4794384 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL4783996 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL4783439 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL4776931 | — | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL4792088 | — | IC50 | = | 285.0 | nM | 6.54 |
| CHEMBL4784024 | — | IC50 | = | 319.0 | nM | 6.50 |
| CHEMBL4786104 | — | IC50 | = | 323.0 | nM | 6.49 |
| CHEMBL4779899 | — | IC50 | = | 334.0 | nM | 6.48 |
| CHEMBL4798735 | — | IC50 | = | 343.0 | nM | 6.46 |
| CHEMBL4790931 | — | IC50 | = | 422.0 | nM | 6.38 |
| CHEMBL4787459 | — | IC50 | = | 557.0 | nM | 6.25 |
| CHEMBL4782349 | — | IC50 | = | 621.0 | nM | 6.21 |
| CHEMBL4782166 | — | IC50 | = | 733.0 | nM | 6.13 |
| CHEMBL4794679 | — | IC50 | = | 832.0 | nM | 6.08 |
| CHEMBL4778648 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL4788093 | — | IC50 | = | 2066.0 | nM | 5.68 |