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Assay Detail

CHEMBL4767291

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 48 hrs by cell-titer-Glo luminescent cell viability assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MV4-11
Confidence 1 — Organism
Curated By Autocuration

Target

MV4-11 (CHEMBL613835)
Type CELL-LINE
Organism Homo sapiens

Publication

Novel Triapine Derivative Induces Copper-Dependent Cell Death in Hematopoietic Cancers.
Chen G,Niu C,Yi J,Sun L,Cao H,Fang Y,Jin T,Li Y,Lou C,Kang J,Wei W,Zhu J
J Med Chem (2019) 62 : 3107 -3121
PubMed 30835473 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 7.11 8.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4790996 1 8.44
CHEMBL4794734 1 8.05
CHEMBL4791298 1 7.65
CHEMBL4799652 1 7.64
CHEMBL4788018 1 7.48
CHEMBL4785612 1 7.47
CHEMBL4798852 1 7.43
CHEMBL4776163 1 7.34
CHEMBL4798008 1 7.24
CHEMBL4792816 1 7.21
CHEMBL4791248 1 6.80
CHEMBL4776233 1 6.75
CHEMBL4786962 1 6.71
CHEMBL231616 TRIAPINE 3.0 1 6.01
CHEMBL4782525 1 5.84
CHEMBL4794669 1 5.70
CHEMBL4779700 1 -
CHEMBL4776446 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4790996 IC50 = 3.6 nM 8.44
CHEMBL4794734 IC50 = 8.9 nM 8.05
CHEMBL4791298 IC50 = 22.3 nM 7.65
CHEMBL4799652 IC50 = 23.0 nM 7.64
CHEMBL4788018 IC50 = 33.4 nM 7.48
CHEMBL4785612 IC50 = 33.5 nM 7.47
CHEMBL4798852 IC50 = 37.3 nM 7.43
CHEMBL4776163 IC50 = 45.3 nM 7.34
CHEMBL4798008 IC50 = 57.1 nM 7.24
CHEMBL4792816 IC50 = 60.9 nM 7.21
CHEMBL4791248 IC50 = 156.8 nM 6.80
CHEMBL4776233 IC50 = 179.5 nM 6.75
CHEMBL4786962 IC50 = 197.1 nM 6.71
CHEMBL231616 TRIAPINE IC50 = 967.6 nM 6.01
CHEMBL4782525 IC50 = 1436.0 nM 5.84
CHEMBL4794669 IC50 = 1988.0 nM 5.70
CHEMBL4779700 IC50 > 50000.0 nM -
CHEMBL4776446 IC50 > 50000.0 nM -