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Assay Detail

CHEMBL4767528

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Functional
Antiviral activity against Rhinovirus B5 infected in human HeLa cell line assessed as inhibition of virus-induced cytopathic effect measured after 72 hrs by crystal violet uptake assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism rhinovirus B5
Confidence 1 — Organism
Curated By Autocuration

Target

rhinovirus B5 (CHEMBL612467)
Type ORGANISM
Organism rhinovirus B5

Publication

Novel pleconaril derivatives: Influence of substituents in the isoxazole and phenyl rings on the antiviral activity against enteroviruses.
Egorova A,Kazakova E,Jahn B,Ekins S,Makarov V,Schmidtke M
Eur J Med Chem (2020) 188 : 112007 -112007
PubMed 31881489 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 5.30 5.76

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4788420 1 5.76
CHEMBL4795797 1 5.48
CHEMBL4785618 1 5.39
CHEMBL4794667 1 5.37
CHEMBL4786215 1 5.28
CHEMBL4790067 1 5.12
CHEMBL4788514 1 4.71
CHEMBL4792115 1 -
CHEMBL4791097 1 -
CHEMBL4787055 1 -
CHEMBL4799461 1 -
CHEMBL4786235 1 -
CHEMBL4782348 1 -
CHEMBL4781680 1 -
CHEMBL4779305 1 -
CHEMBL4785393 1 -
CHEMBL4800213 1 -
CHEMBL4790462 1 -
CHEMBL4786133 1 -
CHEMBL4795869 1 -
CHEMBL4794371 1 -
CHEMBL4776490 1 -
CHEMBL29609 PLECONARIL 2.0 1 -
CHEMBL4788173 1 -
CHEMBL4789714 1 -
CHEMBL4800200 1 -
CHEMBL4793791 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4788420 IC50 = 1740.0 nM 5.76
CHEMBL4795797 IC50 = 3280.0 nM 5.48
CHEMBL4785618 IC50 = 4040.0 nM 5.39
CHEMBL4794667 IC50 = 4280.0 nM 5.37
CHEMBL4786215 IC50 = 5250.0 nM 5.28
CHEMBL4790067 IC50 = 7630.0 nM 5.12
CHEMBL4788514 IC50 = 19440.0 nM 4.71
CHEMBL4792115 IC50 - -
CHEMBL4791097 IC50 - -
CHEMBL4787055 IC50 - -
CHEMBL4799461 IC50 - -
CHEMBL4786235 IC50 - -
CHEMBL4782348 IC50 - -
CHEMBL4781680 IC50 - -
CHEMBL4779305 IC50 - -
CHEMBL4785393 IC50 - -
CHEMBL4800213 IC50 - -
CHEMBL4790462 IC50 - -
CHEMBL4786133 IC50 - -
CHEMBL4795869 IC50 - -
CHEMBL4794371 IC50 - -
CHEMBL4776490 IC50 - -
CHEMBL29609 PLECONARIL IC50 - -
CHEMBL4788173 IC50 - -
CHEMBL4789714 IC50 - -
CHEMBL4800200 IC50 - -
CHEMBL4793791 IC50 - -