Assay Detail
Functional
CHEMBL4767555
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Anti-HIV-1 activity against HTLV-3B infected in human MT2 cells assessed as reduction in syncytium formation by measuring reduction in p24 antigen production measured after 4 days by ELISA method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of quinoxaline compounds as anti-HIV agents targeting reverse transcriptase enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.49 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4784890 | — | — | 1 | 8.51 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 8.17 |
| CHEMBL4796878 | — | — | 1 | 5.80 |
| CHEMBL4778693 | — | — | 1 | - |
| CHEMBL4778138 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4784890 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 6.7 | nM | 8.17 |
| CHEMBL4796878 | — | EC50 | = | 1576.0 | nM | 5.80 |
| CHEMBL4778693 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4778138 | — | EC50 | > | 10000.0 | nM | - |