Assay Detail
Functional
CHEMBL4767671
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Partial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multi-target dopamine D3 receptor modulators: Actionable knowledge for drug design from molecular dynamics and machine learning.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.21 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4092052 | — | — | 1 | 9.00 |
| CHEMBL4090581 | — | — | 1 | 8.44 |
| CHEMBL4117318 | — | — | 1 | 7.75 |
| CHEMBL4785109 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4092052 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4090581 | — | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL4117318 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4785109 | — | EC50 | = | 23.0 | nM | 7.64 |