Assay Detail
Binding
CHEMBL4767839
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human 5-Lipoxygenase using H2DCFDA as substrate preincubated for 5 mins and measured by Spectrophotometric assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.29 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 7.01 |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 6.82 |
| CHEMBL4797429 | — | — | 1 | 4.90 |
| CHEMBL4778192 | — | — | 1 | 4.65 |
| CHEMBL4794879 | — | — | 1 | 4.22 |
| CHEMBL4793947 | — | — | 1 | 4.13 |
| CHEMBL4783536 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL93 | ZILEUTON | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4797429 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL4778192 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL4794879 | — | IC50 | = | 60600.0 | nM | 4.22 |
| CHEMBL4793947 | — | IC50 | = | 74200.0 | nM | 4.13 |
| CHEMBL4783536 | — | IC50 | > | 100000.0 | nM | - |