Assay Detail
Functional
CHEMBL4768022
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Antiproliferative activity against human H1299 cells assessed as reduction in cell viability by MTS assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological activity of N-substituted tetrahydropteroate analogs as non-classical antifolates against cobalamin-dependent methionine synthase and potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.03 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4776344 | — | — | 1 | 7.31 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.14 |
| CHEMBL4777807 | — | — | 1 | 7.03 |
| CHEMBL4796741 | — | — | 1 | 6.92 |
| CHEMBL4778495 | — | — | 1 | 6.80 |
| CHEMBL4787377 | — | — | 1 | 6.68 |
| CHEMBL4789573 | — | — | 1 | 6.64 |
| CHEMBL4798756 | — | — | 1 | 6.62 |
| CHEMBL4794524 | — | — | 1 | 6.39 |
| CHEMBL4798785 | — | — | 1 | 6.36 |
| CHEMBL4788657 | — | — | 1 | 6.33 |
| CHEMBL4794744 | — | — | 1 | 6.24 |
| CHEMBL4791051 | — | — | 1 | 6.18 |
| CHEMBL4795611 | — | — | 1 | 6.00 |
| CHEMBL4793123 | — | — | 1 | 5.01 |
| CHEMBL4782321 | — | — | 1 | 4.80 |
| CHEMBL4794394 | — | — | 1 | 4.75 |
| CHEMBL4781661 | — | — | 1 | 4.73 |
| CHEMBL4793044 | — | — | 1 | 4.50 |
| CHEMBL4799637 | — | — | 1 | 4.07 |
| CHEMBL4792336 | — | — | 1 | - |
| CHEMBL4786618 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4776344 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4777807 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4796741 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4778495 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4787377 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4789573 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4798756 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4794524 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4798785 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4788657 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4794744 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4791051 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4795611 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4793123 | — | IC50 | = | 9750.0 | nM | 5.01 |
| CHEMBL4782321 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL4794394 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL4781661 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL4793044 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL4799637 | — | IC50 | = | 85300.0 | nM | 4.07 |
| CHEMBL4792336 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4786618 | — | IC50 | > | 100000.0 | nM | - |