Assay Detail
Binding
CHEMBL4768130
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Binding affinity to HIV1 NL4-3 capsid protein hexamer assessed as dissociation constant by SPR analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 5.74 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229713 | — | — | 1 | 7.03 |
| CHEMBL4783712 | — | — | 1 | 5.40 |
| CHEMBL4778711 | — | — | 1 | 5.30 |
| CHEMBL4777603 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229713 | — | Kd | = | 92.8 | nM | 7.03 |
| CHEMBL4783712 | — | Kd | = | 4000.0 | nM | 5.40 |
| CHEMBL4778711 | — | Kd | = | 4990.0 | nM | 5.30 |
| CHEMBL4777603 | — | Kd | = | 6040.0 | nM | 5.22 |