Assay Detail
Binding
CHEMBL4768210
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of STEP (unknown origin)
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 5 (CHEMBL2007628) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of striatal-enriched protein tyrosine phosphatase by targeting computationally revealed cryptic pockets.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.04 | 6.96 |
| IC50 | 1 | 7.61 | 7.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3398242 | — | — | 1 | 7.61 |
| CHEMBL4077342 | — | — | 1 | 6.96 |
| CHEMBL2431665 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3398242 | — | IC50 | = | 24.6 | nM | 7.61 |
| CHEMBL4077342 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL2431665 | — | Ki | = | 7800.0 | nM | 5.11 |