Assay Detail
Functional
CHEMBL4768290
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Antiproliferative activity against human HepG2 cells incubated for 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.01 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4794447 | — | — | 1 | 5.19 |
| CHEMBL4789391 | — | — | 1 | 5.12 |
| CHEMBL4794595 | — | — | 1 | 4.96 |
| CHEMBL1331211 | — | — | 1 | 4.94 |
| CHEMBL4782019 | — | — | 1 | 4.93 |
| CHEMBL4788226 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4794447 | — | IC50 | = | 6420.0 | nM | 5.19 |
| CHEMBL4789391 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4794595 | — | IC50 | = | 10980.0 | nM | 4.96 |
| CHEMBL1331211 | — | IC50 | = | 11370.0 | nM | 4.94 |
| CHEMBL4782019 | — | IC50 | = | 11730.0 | nM | 4.93 |
| CHEMBL4788226 | — | IC50 | = | 12690.0 | nM | 4.90 |