Assay Detail
Functional
CHEMBL4768291
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Antiproliferative activity against human RPMI-8226 cells incubated for 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.15 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1331211 | — | — | 1 | 5.24 |
| CHEMBL4794447 | — | — | 1 | 5.20 |
| CHEMBL4788226 | — | — | 1 | 5.13 |
| CHEMBL4782019 | — | — | 1 | 5.12 |
| CHEMBL4789391 | — | — | 1 | 5.12 |
| CHEMBL4794595 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1331211 | — | IC50 | = | 5770.0 | nM | 5.24 |
| CHEMBL4794447 | — | IC50 | = | 6340.0 | nM | 5.20 |
| CHEMBL4788226 | — | IC50 | = | 7350.0 | nM | 5.13 |
| CHEMBL4782019 | — | IC50 | = | 7610.0 | nM | 5.12 |
| CHEMBL4789391 | — | IC50 | = | 7670.0 | nM | 5.12 |
| CHEMBL4794595 | — | IC50 | = | 8610.0 | nM | 5.07 |