Assay Detail
Binding
CHEMBL4768322
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus (A/goose/Guangdong/SH7/2013(H5N1)) group-1 Neuraminidase N1 preincubated for 10 mins followed by MUNANA substrate addition and measured after 40 to 60 mins by fluorescence method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of novel "Dual-site" binding oseltamivir derivatives as potent influenza virus neuraminidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.22 | 8.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.78 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 7.69 |
| CHEMBL4784537 | — | — | 1 | 7.65 |
| CHEMBL4788464 | — | — | 1 | 7.48 |
| CHEMBL4793273 | — | — | 1 | 7.27 |
| CHEMBL4785103 | — | — | 1 | 7.24 |
| CHEMBL4778066 | — | — | 1 | 7.13 |
| CHEMBL4788913 | — | — | 1 | 6.93 |
| CHEMBL4781455 | — | — | 1 | 6.89 |
| CHEMBL4797291 | — | — | 1 | 6.59 |
| CHEMBL4784077 | — | — | 1 | 6.58 |
| CHEMBL4795384 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 1.66 | nM | 8.78 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 20.61 | nM | 7.69 |
| CHEMBL4784537 | — | IC50 | = | 22.39 | nM | 7.65 |
| CHEMBL4788464 | — | IC50 | = | 33.26 | nM | 7.48 |
| CHEMBL4793273 | — | IC50 | = | 53.99 | nM | 7.27 |
| CHEMBL4785103 | — | IC50 | = | 57.66 | nM | 7.24 |
| CHEMBL4778066 | — | IC50 | = | 74.82 | nM | 7.13 |
| CHEMBL4788913 | — | IC50 | = | 118.17 | nM | 6.93 |
| CHEMBL4781455 | — | IC50 | = | 129.28 | nM | 6.89 |
| CHEMBL4797291 | — | IC50 | = | 254.2 | nM | 6.59 |
| CHEMBL4784077 | — | IC50 | = | 264.03 | nM | 6.58 |
| CHEMBL4795384 | — | IC50 | = | 391.5 | nM | 6.41 |