Assay Detail
Binding
CHEMBL4768325
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus (A/goose/Jiangsu/1306/2014 (H5N8)) group-1 Neuraminidase N8 preincubated for 10 mins followed by MUNANA substrate addition and measured after 40 to 60 mins by fluorescence method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of novel "Dual-site" binding oseltamivir derivatives as potent influenza virus neuraminidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.21 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 8.05 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.00 |
| CHEMBL4788464 | — | — | 1 | 7.48 |
| CHEMBL4778066 | — | — | 1 | 7.26 |
| CHEMBL4797291 | — | — | 1 | 7.21 |
| CHEMBL4788913 | — | — | 1 | 7.11 |
| CHEMBL4793273 | — | — | 1 | 7.08 |
| CHEMBL4784077 | — | — | 1 | 7.04 |
| CHEMBL4785103 | — | — | 1 | 7.03 |
| CHEMBL4795384 | — | — | 1 | 6.96 |
| CHEMBL4784537 | — | — | 1 | 6.76 |
| CHEMBL4781455 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 8.81 | nM | 8.05 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 9.99 | nM | 8.00 |
| CHEMBL4788464 | — | IC50 | = | 33.02 | nM | 7.48 |
| CHEMBL4778066 | — | IC50 | = | 55.25 | nM | 7.26 |
| CHEMBL4797291 | — | IC50 | = | 62.09 | nM | 7.21 |
| CHEMBL4788913 | — | IC50 | = | 78.06 | nM | 7.11 |
| CHEMBL4793273 | — | IC50 | = | 83.13 | nM | 7.08 |
| CHEMBL4784077 | — | IC50 | = | 90.06 | nM | 7.04 |
| CHEMBL4785103 | — | IC50 | = | 92.61 | nM | 7.03 |
| CHEMBL4795384 | — | IC50 | = | 108.57 | nM | 6.96 |
| CHEMBL4784537 | — | IC50 | = | 174.4 | nM | 6.76 |
| CHEMBL4781455 | — | IC50 | = | 309.0 | nM | 6.51 |