Assay Detail
Binding
CHEMBL4768327
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Inhibition of Influenza A virus (A/California/04/2009(H1N1)) pdm09 Neuraminidase N1 preincubated for 10 mins followed by MUNANA substrate addition and measured after 40 to 60 mins by fluorescence method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/California/04/2009(H1N1)) |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of novel "Dual-site" binding oseltamivir derivatives as potent influenza virus neuraminidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 9.46 | 10.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 10.39 |
| CHEMBL4781455 | — | — | 1 | 10.06 |
| CHEMBL4784077 | — | — | 1 | 9.51 |
| CHEMBL4785103 | — | — | 1 | 9.37 |
| CHEMBL4788464 | — | — | 1 | 9.37 |
| CHEMBL4788913 | — | — | 1 | 9.32 |
| CHEMBL4778066 | — | — | 1 | 9.22 |
| CHEMBL4784537 | — | — | 1 | 9.08 |
| CHEMBL4795384 | — | — | 1 | 8.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 0.041 | nM | 10.39 |
| CHEMBL4781455 | — | IC50 | = | 0.087 | nM | 10.06 |
| CHEMBL4784077 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL4785103 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL4788464 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL4788913 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL4778066 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4784537 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL4795384 | — | IC50 | = | 1.67 | nM | 8.78 |