Assay Detail
Binding
CHEMBL4768524
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of human recombinant lysosomal GCase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 45 mins followed by substrate addition and measured after 30 mins by fluorescence spectrophotometry based Lineweaver-Burk plot analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of multimeric pyrrolidine iminosugar inhibitors of human β-glucocerebrosidase and α-galactosidase A: First example of a multivalent enzyme activity enhancer for Fabry disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.35 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4792854 | — | — | 1 | 6.11 |
| CHEMBL4783905 | — | — | 1 | 5.96 |
| CHEMBL4793095 | — | — | 1 | 5.92 |
| CHEMBL4791125 | — | — | 1 | 5.80 |
| CHEMBL4782789 | — | — | 1 | 5.58 |
| CHEMBL4779198 | — | — | 1 | 5.57 |
| CHEMBL4793871 | — | — | 1 | 5.27 |
| CHEMBL4218664 | — | — | 1 | 4.72 |
| CHEMBL4214414 | — | — | 1 | 4.26 |
| CHEMBL4786169 | — | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4792854 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL4783905 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL4793095 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL4791125 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL4782789 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL4779198 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL4793871 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL4218664 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL4214414 | — | Ki | = | 55000.0 | nM | 4.26 |
| CHEMBL4786169 | — | Ki | = | 55000.0 | nM | 4.26 |