Assay Detail
Binding
CHEMBL4768533
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human C-terminal His/FLAG-tagged HDAC1 (1 to end residues) expressed in sf9 insect cells using Boc-Lys(Ac)-AMC as substrate incubated for 60 mins by fluorescence assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel indazole-based derivatives as potent HDAC inhibitors via fragment-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.18 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4786031 | — | — | 1 | 8.74 |
| CHEMBL4790137 | — | — | 1 | 8.72 |
| CHEMBL4776328 | — | — | 1 | 8.68 |
| CHEMBL4777182 | — | — | 1 | 8.62 |
| CHEMBL4782066 | — | — | 1 | 8.60 |
| CHEMBL4782988 | — | — | 1 | 8.59 |
| CHEMBL4792567 | — | — | 1 | 8.57 |
| CHEMBL4788954 | — | — | 1 | 8.57 |
| CHEMBL4799886 | — | — | 1 | 8.52 |
| CHEMBL4776974 | — | — | 1 | 8.51 |
| CHEMBL4786350 | — | — | 1 | 8.51 |
| CHEMBL4793650 | — | — | 1 | 8.47 |
| CHEMBL4792980 | — | — | 1 | 8.43 |
| CHEMBL4786063 | — | — | 1 | 8.34 |
| CHEMBL4788942 | — | — | 1 | 8.34 |
| CHEMBL4776599 | — | — | 1 | 8.22 |
| CHEMBL4782327 | — | — | 1 | 8.02 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.89 |
| CHEMBL4797623 | — | — | 1 | 7.89 |
| CHEMBL4792025 | — | — | 1 | 7.64 |
| CHEMBL4792705 | — | — | 1 | 7.44 |
| CHEMBL4779831 | — | — | 1 | 7.12 |
| CHEMBL4784481 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4786031 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4790137 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4776328 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4777182 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4782066 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4782988 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4792567 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4788954 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4799886 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4776974 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4786350 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4793650 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4792980 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4786063 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4788942 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4776599 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4782327 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4797623 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4792025 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4792705 | — | IC50 | = | 36.2 | nM | 7.44 |
| CHEMBL4779831 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4784481 | — | IC50 | = | 2425.0 | nM | 5.62 |