Assay Detail
Functional
CHEMBL4768558
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Inhibition of collagen-induced platelet aggregation in human platelet preincubated for 5 mins followed by collagen-stimulation and measured after 6 mins by lumi-aggregometric method
14
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Platelet |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of antiplatelet ortho-carbonyl hydroquinones with differential action on platelet aggregation stimulated by collagen or TRAP-6.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.00 | 5.75 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4795847 | — | — | 2 | 5.75 |
| CHEMBL398435 | TICAGRELOR | 4.0 | 1 | 5.70 |
| CHEMBL239903 | — | — | 1 | 5.36 |
| CHEMBL394681 | — | — | 1 | 4.94 |
| CHEMBL4786818 | — | — | 1 | 4.92 |
| CHEMBL239687 | — | — | 1 | 4.84 |
| CHEMBL4780580 | — | — | 2 | 4.77 |
| CHEMBL239688 | — | — | 1 | 4.69 |
| CHEMBL4776370 | — | — | 1 | 4.59 |
| CHEMBL4778303 | — | — | 1 | 4.45 |
| CHEMBL4793977 | — | — | 1 | - |
| CHEMBL4781257 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4795847 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL398435 | TICAGRELOR | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL239903 | — | IC50 | = | 4380.0 | nM | 5.36 |
| CHEMBL394681 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL4786818 | — | IC50 | = | 11970.0 | nM | 4.92 |
| CHEMBL239687 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL4780580 | — | IC50 | = | 17120.0 | nM | 4.77 |
| CHEMBL239688 | — | IC50 | = | 20580.0 | nM | 4.69 |
| CHEMBL4776370 | — | IC50 | = | 25510.0 | nM | 4.59 |
| CHEMBL4778303 | — | IC50 | = | 35340.0 | nM | 4.45 |
| CHEMBL4795847 | — | Inhibition | - | % | - | |
| CHEMBL4780580 | — | Inhibition | - | % | - | |
| CHEMBL4793977 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4781257 | — | IC50 | > | 100000.0 | nM | - |