Assay Detail
Functional
CHEMBL4768587
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth inhibition measured after 4 to 6 days by celltiter-glo luminescent cell viability assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a novel series of imidazo[1',2':1,6]pyrido[2,3-d]pyrimidin derivatives as potent cyclin-dependent kinase 4/6 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.82 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4778367 | — | — | 1 | 6.06 |
| CHEMBL4776781 | — | — | 1 | 6.01 |
| CHEMBL3301610 | ABEMACICLIB | 4.0 | 1 | 5.94 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4778367 | — | IC50 | = | 874.5 | nM | 6.06 |
| CHEMBL4776781 | — | IC50 | = | 983.6 | nM | 6.01 |
| CHEMBL3301610 | ABEMACICLIB | IC50 | = | 1144.0 | nM | 5.94 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 5424.0 | nM | 5.27 |