Assay Detail
Binding
CHEMBL4768628
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK1/cyclin B (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B1 (CHEMBL1907602) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Discovery of a novel series of imidazo[1',2':1,6]pyrido[2,3-d]pyrimidin derivatives as potent cyclin-dependent kinase 4/6 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.26 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3301610 | ABEMACICLIB | 4.0 | 1 | 6.58 |
| CHEMBL4778367 | — | — | 1 | 6.51 |
| CHEMBL4776781 | — | — | 1 | 5.68 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3301610 | ABEMACICLIB | IC50 | = | 263.2 | nM | 6.58 |
| CHEMBL4778367 | — | IC50 | = | 309.2 | nM | 6.51 |
| CHEMBL4776781 | — | IC50 | = | 2084.0 | nM | 5.68 |
| CHEMBL189963 | PALBOCICLIB | IC50 | > | 3333.0 | nM | - |