Assay Detail
Functional
CHEMBL4768896
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel dual-acting modulators targeting both estrogen receptor α (ERα) and lysine-specific demethylase 1 (LSD1) for treatment of breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.73 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4793041 | — | — | 1 | 5.39 |
| CHEMBL4789998 | — | — | 1 | 5.39 |
| CHEMBL4794190 | — | — | 1 | 5.11 |
| CHEMBL4785653 | — | — | 1 | 5.10 |
| CHEMBL4796734 | — | — | 1 | 5.06 |
| CHEMBL489 | AFIMOXIFENE | 3.0 | 1 | 5.02 |
| CHEMBL4776965 | — | — | 1 | 4.99 |
| CHEMBL4799753 | — | — | 1 | 4.90 |
| CHEMBL4776528 | — | — | 1 | 4.86 |
| CHEMBL4782721 | — | — | 1 | 4.82 |
| CHEMBL4785999 | — | — | 1 | 4.78 |
| CHEMBL4776324 | — | — | 1 | 4.78 |
| CHEMBL4779241 | — | — | 1 | 4.73 |
| CHEMBL4779506 | — | — | 1 | 4.58 |
| CHEMBL4800654 | — | — | 1 | 4.54 |
| CHEMBL4780242 | — | — | 1 | 4.52 |
| CHEMBL4779333 | — | — | 1 | 4.52 |
| CHEMBL4796248 | — | — | 1 | 4.45 |
| CHEMBL4790660 | — | — | 1 | 4.42 |
| CHEMBL4786502 | — | — | 1 | 4.42 |
| CHEMBL4798153 | — | — | 1 | 4.42 |
| CHEMBL4789234 | — | — | 1 | 4.35 |
| CHEMBL4788320 | — | — | 1 | 4.31 |
| CHEMBL4779659 | — | — | 1 | 4.08 |
| CHEMBL4783907 | — | — | 1 | - |
| CHEMBL3989843 | TRANYLCYPROMINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4793041 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4789998 | — | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL4794190 | — | IC50 | = | 7840.0 | nM | 5.11 |
| CHEMBL4785653 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4796734 | — | IC50 | = | 8790.0 | nM | 5.06 |
| CHEMBL489 | AFIMOXIFENE | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4776965 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL4799753 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL4776528 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL4782721 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL4785999 | — | IC50 | = | 16720.0 | nM | 4.78 |
| CHEMBL4776324 | — | IC50 | = | 16450.0 | nM | 4.78 |
| CHEMBL4779241 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL4779506 | — | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL4800654 | — | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL4780242 | — | IC50 | = | 30480.0 | nM | 4.52 |
| CHEMBL4779333 | — | IC50 | = | 30200.0 | nM | 4.52 |
| CHEMBL4796248 | — | IC50 | = | 35200.0 | nM | 4.45 |
| CHEMBL4790660 | — | IC50 | = | 38300.0 | nM | 4.42 |
| CHEMBL4786502 | — | IC50 | = | 38200.0 | nM | 4.42 |
| CHEMBL4798153 | — | IC50 | = | 37700.0 | nM | 4.42 |
| CHEMBL4789234 | — | IC50 | = | 44500.0 | nM | 4.35 |
| CHEMBL4788320 | — | IC50 | = | 49400.0 | nM | 4.31 |
| CHEMBL4779659 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL4783907 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3989843 | TRANYLCYPROMINE | IC50 | > | 100000.0 | nM | - |