Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4768936

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Plasmodium falciparum DHFR N51I/C59R/S108N mutant expressed in Escherichia coli BL21 using DHF as substrate by spectrophotometric analysis
ChEMBL ↗
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Plasmodium falciparum
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Flexible diaminodihydrotriazine inhibitors of Plasmodium falciparum dihydrofolate reductase: Binding strengths, modes of binding and their antimalarial activities.
Kamchonwongpaisan S,Charoensetakul N,Srisuwannaket C,Taweechai S,Rattanajak R,Vanichtanankul J,Vitsupakorn D,Arwon U,Thongpanchang C,Tarnchompoo B,Vilaivan T,Yuthavong Y
Eur J Med Chem (2020) 195 : 112263 -112263
PubMed 32294614 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 49 8.76 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL587606 — — 1 9.52
CHEMBL4780298 — — 1 9.40
CHEMBL4782529 — — 1 9.40
CHEMBL4798754 — — 1 9.22
CHEMBL4780381 — — 1 9.22
CHEMBL4792349 — — 1 9.22
CHEMBL4778245 — — 1 9.15
CHEMBL4789322 — — 1 9.15
CHEMBL1231612 — — 1 9.15
CHEMBL4798400 — — 1 9.15
CHEMBL4795771 — — 1 9.15
CHEMBL4800011 — — 1 9.10
CHEMBL4780256 — — 1 9.10
CHEMBL4796933 — — 1 9.10
CHEMBL4792035 — — 1 9.10
CHEMBL4784036 — — 1 9.10
CHEMBL4781162 — — 1 9.05
CHEMBL4784738 — — 1 9.05
CHEMBL4793034 — — 1 8.96
CHEMBL129788 — — 1 8.96
CHEMBL4783968 — — 1 8.96
CHEMBL4796554 — — 1 8.92
CHEMBL4781827 — — 1 8.92
CHEMBL4795829 — — 1 8.92
CHEMBL4781149 — — 1 8.85
CHEMBL4793581 — — 1 8.82
CHEMBL4799272 — — 1 8.82
CHEMBL527468 — — 1 8.80
CHEMBL4800362 — — 1 8.80
CHEMBL4800635 — — 1 8.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL587606 — Ki = 0.3 nM 9.52
CHEMBL4780298 — Ki = 0.4 nM 9.40
CHEMBL4782529 — Ki = 0.4 nM 9.40
CHEMBL4798754 — Ki = 0.6 nM 9.22
CHEMBL4780381 — Ki = 0.6 nM 9.22
CHEMBL4792349 — Ki = 0.6 nM 9.22
CHEMBL4778245 — Ki = 0.7 nM 9.15
CHEMBL4789322 — Ki = 0.7 nM 9.15
CHEMBL1231612 — Ki = 0.7 nM 9.15
CHEMBL4798400 — Ki = 0.7 nM 9.15
CHEMBL4795771 — Ki = 0.7 nM 9.15
CHEMBL4784036 — Ki = 0.8 nM 9.10
CHEMBL4800011 — Ki = 0.8 nM 9.10
CHEMBL4780256 — Ki = 0.8 nM 9.10
CHEMBL4796933 — Ki = 0.8 nM 9.10
CHEMBL4792035 — Ki = 0.8 nM 9.10
CHEMBL4781162 — Ki = 0.9 nM 9.05
CHEMBL4784738 — Ki = 0.9 nM 9.05
CHEMBL4793034 — Ki = 1.1 nM 8.96
CHEMBL129788 — Ki = 1.1 nM 8.96
CHEMBL4783968 — Ki = 1.1 nM 8.96
CHEMBL4796554 — Ki = 1.2 nM 8.92
CHEMBL4795829 — Ki = 1.2 nM 8.92
CHEMBL4781827 — Ki = 1.2 nM 8.92
CHEMBL4781149 — Ki = 1.4 nM 8.85
CHEMBL4799272 — Ki = 1.5 nM 8.82
CHEMBL4793581 — Ki = 1.5 nM 8.82
CHEMBL527468 — Ki = 1.6 nM 8.80
CHEMBL4800362 — Ki = 1.6 nM 8.80
CHEMBL4800635 — Ki = 2.0 nM 8.70
CHEMBL4797103 — Ki = 2.1 nM 8.68
CHEMBL4796443 — Ki = 2.2 nM 8.66
CHEMBL4791022 — Ki = 2.6 nM 8.59
CHEMBL4798412 — Ki = 2.6 nM 8.59
CHEMBL4777058 — Ki = 2.9 nM 8.54
CHEMBL528489 — Ki = 2.9 nM 8.54
CHEMBL4799632 — Ki = 3.1 nM 8.51
CHEMBL4798973 — Ki = 4.0 nM 8.40
CHEMBL4788495 — Ki = 4.1 nM 8.39
CHEMBL4784378 — Ki = 4.3 nM 8.37
CHEMBL4789860 — Ki = 5.8 nM 8.24
CHEMBL4796828 — Ki = 5.9 nM 8.23
CHEMBL4791594 — Ki = 6.7 nM 8.17
CHEMBL4781350 — Ki = 7.5 nM 8.12
CHEMBL4779476 — Ki = 10.0 nM 8.00
CHEMBL4786930 — Ki = 10.2 nM 7.99
CHEMBL4786084 — Ki = 10.2 nM 7.99
CHEMBL4789386 — Ki = 17.9 nM 7.75
CHEMBL747 CYCLOGUANIL Ki = 31.4 nM 7.50