Assay Detail
ADMET
CHEMBL4768949
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Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Chlorocebus sabaeus |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Flexible diaminodihydrotriazine inhibitors of Plasmodium falciparum dihydrofolate reductase: Binding strengths, modes of binding and their antimalarial activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.87 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4780381 | — | — | 1 | 6.77 |
| CHEMBL4795771 | — | — | 1 | 5.41 |
| CHEMBL4792349 | — | — | 1 | 5.23 |
| CHEMBL4796554 | — | — | 1 | 5.15 |
| CHEMBL1231612 | — | — | 1 | 5.01 |
| CHEMBL527468 | — | — | 1 | 5.01 |
| CHEMBL528489 | — | — | 1 | 4.92 |
| CHEMBL4796933 | — | — | 1 | 4.85 |
| CHEMBL4798400 | — | — | 1 | 4.84 |
| CHEMBL4789322 | — | — | 1 | 4.74 |
| CHEMBL4782529 | — | — | 1 | 4.67 |
| CHEMBL4800362 | — | — | 1 | 4.60 |
| CHEMBL4778245 | — | — | 1 | 4.57 |
| CHEMBL4784036 | — | — | 1 | 4.48 |
| CHEMBL4799272 | — | — | 1 | 4.48 |
| CHEMBL4793581 | — | — | 1 | 4.35 |
| CHEMBL4780298 | — | — | 1 | 4.34 |
| CHEMBL587606 | — | — | 1 | 4.20 |
| CHEMBL4792035 | — | — | 1 | - |
| CHEMBL4784738 | — | — | 1 | - |
| CHEMBL4781149 | — | — | 1 | - |
| CHEMBL4781162 | — | — | 1 | - |
| CHEMBL129788 | — | — | 1 | - |
| CHEMBL4797103 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4780381 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4795771 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4792349 | — | IC50 | = | 5910.0 | nM | 5.23 |
| CHEMBL4796554 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL1231612 | — | IC50 | = | 9710.0 | nM | 5.01 |
| CHEMBL527468 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL528489 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4796933 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4798400 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL4789322 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL4782529 | — | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL4800362 | — | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL4778245 | — | IC50 | = | 27100.0 | nM | 4.57 |
| CHEMBL4784036 | — | IC50 | = | 33300.0 | nM | 4.48 |
| CHEMBL4799272 | — | IC50 | = | 33300.0 | nM | 4.48 |
| CHEMBL4793581 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL4780298 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL587606 | — | IC50 | = | 63800.0 | nM | 4.20 |
| CHEMBL4792035 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4784738 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4781149 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4781162 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL129788 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4797103 | — | IC50 | > | 50000.0 | nM | - |