Assay Detail
ADMET
CHEMBL4769112
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Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.09 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4779166 | — | — | 1 | 5.54 |
| CHEMBL4796639 | — | — | 1 | 5.42 |
| CHEMBL4799798 | — | — | 1 | 5.17 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 5.14 |
| CHEMBL13976 | — | — | 1 | 4.90 |
| CHEMBL3542344 | — | — | 1 | 4.87 |
| CHEMBL4788980 | — | — | 1 | 4.87 |
| CHEMBL4788376 | — | — | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4779166 | — | EC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL4796639 | — | EC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL4799798 | — | EC50 | = | 6790.0 | nM | 5.17 |
| CHEMBL535 | SUNITINIB | EC50 | = | 7230.0 | nM | 5.14 |
| CHEMBL13976 | — | EC50 | = | 12550.0 | nM | 4.90 |
| CHEMBL3542344 | — | EC50 | = | 13590.0 | nM | 4.87 |
| CHEMBL4788980 | — | EC50 | = | 13480.0 | nM | 4.87 |
| CHEMBL4788376 | — | EC50 | = | 14780.0 | nM | 4.83 |