Assay Detail
ADMET
CHEMBL4769128
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Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs by celltox-green assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.02 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4786972 | — | — | 1 | 5.38 |
| CHEMBL4796639 | — | — | 1 | 5.32 |
| CHEMBL4799798 | — | — | 1 | 5.16 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 5.15 |
| CHEMBL4779166 | — | — | 1 | 5.15 |
| CHEMBL3542344 | — | — | 1 | 4.92 |
| CHEMBL13976 | — | — | 1 | 4.88 |
| CHEMBL4788980 | — | — | 1 | 4.88 |
| CHEMBL4794096 | — | — | 1 | 4.87 |
| CHEMBL4788376 | — | — | 1 | 4.87 |
| CHEMBL4781578 | — | — | 1 | 4.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4786972 | — | EC50 | = | 4180.0 | nM | 5.38 |
| CHEMBL4796639 | — | EC50 | = | 4810.0 | nM | 5.32 |
| CHEMBL4799798 | — | EC50 | = | 6910.0 | nM | 5.16 |
| CHEMBL535 | SUNITINIB | EC50 | = | 7030.0 | nM | 5.15 |
| CHEMBL4779166 | — | EC50 | = | 7150.0 | nM | 5.15 |
| CHEMBL3542344 | — | EC50 | = | 11880.0 | nM | 4.92 |
| CHEMBL13976 | — | EC50 | = | 13030.0 | nM | 4.88 |
| CHEMBL4788980 | — | EC50 | = | 13270.0 | nM | 4.88 |
| CHEMBL4794096 | — | EC50 | = | 13580.0 | nM | 4.87 |
| CHEMBL4788376 | — | EC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL4781578 | — | EC50 | = | 20450.0 | nM | 4.69 |