Assay Detail
Functional
CHEMBL4769197
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Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a chiral fluorinated azetidin-2-one as a tubulin polymerisation inhibitor with potent antitumour efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.38 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4789173 | — | — | 1 | 8.52 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.52 |
| CHEMBL4789474 | — | — | 1 | 8.05 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.00 |
| CHEMBL4787052 | — | — | 1 | 7.92 |
| CHEMBL4789522 | — | — | 1 | 7.89 |
| CHEMBL4780811 | — | — | 1 | 7.70 |
| CHEMBL4293724 | — | — | 1 | 7.68 |
| CHEMBL4786396 | — | — | 1 | 7.64 |
| CHEMBL4782138 | — | — | 1 | 7.58 |
| CHEMBL4786049 | — | — | 1 | 7.47 |
| CHEMBL4787486 | — | — | 1 | 7.44 |
| CHEMBL4781487 | — | — | 1 | 7.36 |
| CHEMBL4784116 | — | — | 1 | 7.33 |
| CHEMBL4794347 | — | — | 1 | 7.30 |
| CHEMBL4780330 | — | — | 1 | 7.28 |
| CHEMBL4783564 | — | — | 1 | 7.24 |
| CHEMBL4779591 | — | — | 1 | 7.17 |
| CHEMBL4778359 | — | — | 1 | 7.12 |
| CHEMBL4778781 | — | — | 1 | 6.97 |
| CHEMBL4784374 | — | — | 1 | 6.85 |
| CHEMBL4797174 | — | — | 1 | 6.80 |
| CHEMBL4790056 | — | — | 1 | 6.63 |
| CHEMBL4799279 | — | — | 1 | 6.62 |
| CHEMBL4797153 | — | — | 1 | 6.60 |
| CHEMBL4790646 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4789173 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4789474 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4787052 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4789522 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4780811 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4293724 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4786396 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4782138 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4786049 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4787486 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4781487 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4784116 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4794347 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4780330 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4783564 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4779591 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4778359 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL4778781 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL4784374 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL4797174 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL4790056 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL4799279 | — | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL4797153 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4790646 | — | IC50 | = | 489.0 | nM | 6.31 |