Assay Detail
Binding
CHEMBL4769202
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of pig brain tubulin polymerization by absorbance based analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a chiral fluorinated azetidin-2-one as a tubulin polymerisation inhibitor with potent antitumour efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.44 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4789173 | — | — | 1 | 6.00 |
| CHEMBL4293724 | — | — | 1 | 5.46 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 4.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4789173 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4293724 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL107 | COLCHICINE | IC50 | = | 13400.0 | nM | 4.87 |