Assay Detail
Binding
CHEMBL4769705
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ALK5 (unknown origin) measured after 120 mins of incubation by ADP-Glo kinase assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 4-(pyridin-4-oxy)-3-(3,3-difluorocyclobutyl)-pyrazole derivatives as novel potent transforming growth factor-β type 1 receptor inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.27 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4782867 | — | — | 1 | 8.09 |
| CHEMBL4797447 | — | — | 1 | 8.09 |
| CHEMBL4791582 | — | — | 1 | 7.94 |
| CHEMBL4777294 | — | — | 1 | 7.88 |
| CHEMBL4788502 | — | — | 1 | 7.88 |
| CHEMBL4792452 | — | — | 1 | 7.71 |
| CHEMBL4784194 | — | — | 1 | 7.66 |
| CHEMBL4780548 | — | — | 1 | 7.61 |
| CHEMBL4777871 | — | — | 1 | 7.58 |
| CHEMBL4786439 | — | — | 1 | 7.58 |
| CHEMBL4797329 | — | — | 1 | 7.56 |
| CHEMBL4781586 | — | — | 1 | 7.52 |
| CHEMBL4790322 | — | — | 1 | 7.50 |
| CHEMBL4791955 | — | — | 1 | 7.50 |
| CHEMBL4778362 | — | — | 1 | 7.46 |
| CHEMBL4594432 | LY-3200882 | 1.0 | 1 | 7.42 |
| CHEMBL4791815 | — | — | 1 | 7.36 |
| CHEMBL4788673 | — | — | 1 | 7.36 |
| CHEMBL4795823 | — | — | 1 | 7.33 |
| CHEMBL4784622 | — | — | 1 | 7.21 |
| CHEMBL4781326 | — | — | 1 | 7.16 |
| CHEMBL4777610 | — | — | 1 | 7.08 |
| CHEMBL4781452 | — | — | 1 | 6.55 |
| CHEMBL4799736 | — | — | 1 | 6.51 |
| CHEMBL4795745 | — | — | 1 | 6.38 |
| CHEMBL4783147 | — | — | 1 | 6.28 |
| CHEMBL4794175 | — | — | 1 | 6.09 |
| CHEMBL4784607 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4782867 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL4797447 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL4791582 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL4777294 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL4788502 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL4792452 | — | IC50 | = | 19.7 | nM | 7.71 |
| CHEMBL4784194 | — | IC50 | = | 21.7 | nM | 7.66 |
| CHEMBL4780548 | — | IC50 | = | 24.3 | nM | 7.61 |
| CHEMBL4777871 | — | IC50 | = | 26.2 | nM | 7.58 |
| CHEMBL4786439 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4797329 | — | IC50 | = | 27.5 | nM | 7.56 |
| CHEMBL4781586 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL4790322 | — | IC50 | = | 31.4 | nM | 7.50 |
| CHEMBL4791955 | — | IC50 | = | 31.4 | nM | 7.50 |
| CHEMBL4778362 | — | IC50 | = | 34.6 | nM | 7.46 |
| CHEMBL4594432 | LY-3200882 | IC50 | = | 38.2 | nM | 7.42 |
| CHEMBL4791815 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4788673 | — | IC50 | = | 44.2 | nM | 7.36 |
| CHEMBL4795823 | — | IC50 | = | 47.2 | nM | 7.33 |
| CHEMBL4784622 | — | IC50 | = | 61.3 | nM | 7.21 |
| CHEMBL4781326 | — | IC50 | = | 69.2 | nM | 7.16 |
| CHEMBL4777610 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4781452 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL4799736 | — | IC50 | = | 308.0 | nM | 6.51 |
| CHEMBL4795745 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL4783147 | — | IC50 | = | 528.0 | nM | 6.28 |
| CHEMBL4794175 | — | IC50 | = | 814.0 | nM | 6.09 |
| CHEMBL4784607 | — | IC50 | = | 6736.0 | nM | 5.17 |