Assay Detail
ADMET
CHEMBL4770080
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Cytotoxicity against human L0-2 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | L02 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of new thieno[3,2-d]pyrimidine derivatives targeting EGFR NSCLCs by the conformation constrained strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.41 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3786343 | OLMUTINIB | 4.0 | 1 | 7.58 |
| CHEMBL4780855 | — | — | 1 | 5.50 |
| CHEMBL4791108 | — | — | 1 | 5.36 |
| CHEMBL4785528 | — | — | 1 | 5.28 |
| CHEMBL4779681 | — | — | 1 | 5.25 |
| CHEMBL4800533 | — | — | 1 | 5.17 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.15 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 5.14 |
| CHEMBL4791953 | — | — | 1 | 5.10 |
| CHEMBL4782898 | — | — | 1 | 5.08 |
| CHEMBL4776694 | — | — | 1 | 4.90 |
| CHEMBL4781497 | — | — | 1 | - |
| CHEMBL4794102 | — | — | 1 | - |
| CHEMBL4798996 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3786343 | OLMUTINIB | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4780855 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4791108 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4785528 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL4779681 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4800533 | — | IC50 | = | 6760.0 | nM | 5.17 |
| CHEMBL939 | GEFITINIB | IC50 | = | 7140.0 | nM | 5.15 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 7250.0 | nM | 5.14 |
| CHEMBL4791953 | — | IC50 | = | 7990.0 | nM | 5.10 |
| CHEMBL4782898 | — | IC50 | = | 8370.0 | nM | 5.08 |
| CHEMBL4776694 | — | IC50 | = | 12470.0 | nM | 4.90 |
| CHEMBL4781497 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4794102 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4798996 | — | IC50 | > | 20000.0 | nM | - |