Assay Detail
ADMET
CHEMBL4770093
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human K562/4 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | K562/4 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel curcumin derivatives as P-glycoprotein inhibitors: Molecular modeling, synthesis and sensitization of multidrug resistant cells to doxorubicin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.04 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4785467 | — | — | 1 | 5.37 |
| CHEMBL4781431 | — | — | 1 | 5.27 |
| CHEMBL4790168 | — | — | 1 | 5.19 |
| CHEMBL4785124 | — | — | 1 | 5.02 |
| CHEMBL4782247 | — | — | 1 | 4.99 |
| CHEMBL4799626 | — | — | 1 | 4.99 |
| CHEMBL258739 | — | — | 1 | 4.97 |
| CHEMBL4786729 | — | — | 1 | 4.96 |
| CHEMBL4782815 | — | — | 1 | 4.90 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 4.74 |
| CHEMBL4787636 | — | — | 1 | - |
| CHEMBL4784723 | — | — | 1 | - |
| CHEMBL4799723 | — | — | 1 | - |
| CHEMBL4790731 | — | — | 1 | - |
| CHEMBL4784954 | — | — | 1 | - |
| CHEMBL4789726 | — | — | 1 | - |
| CHEMBL4796241 | — | — | 1 | - |
| CHEMBL4796816 | — | — | 1 | - |
| CHEMBL4779413 | — | — | 1 | - |
| CHEMBL4787174 | — | — | 1 | - |
| CHEMBL4791009 | — | — | 1 | - |
| CHEMBL4778709 | — | — | 1 | - |
| CHEMBL4798062 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4785467 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4781431 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4790168 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4785124 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4782247 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4799626 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL258739 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL4786729 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL4782815 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL4787636 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4784723 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4799723 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4790731 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4784954 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4789726 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4796241 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4796816 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4779413 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4787174 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4791009 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4778709 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4798062 | — | IC50 | > | 25000.0 | nM | - |