Assay Detail
Functional
CHEMBL4770223
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.13 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4795215 | — | — | 1 | 8.96 |
| CHEMBL4784348 | — | — | 1 | 8.55 |
| CHEMBL4786045 | — | — | 1 | 8.54 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.40 |
| CHEMBL4782713 | — | — | 1 | 8.35 |
| CHEMBL522420 | — | — | 1 | 8.21 |
| CHEMBL1823159 | — | — | 1 | 7.82 |
| CHEMBL4786603 | — | — | 1 | 7.64 |
| CHEMBL4795928 | — | — | 1 | 7.25 |
| CHEMBL4795914 | — | — | 1 | 6.38 |
| CHEMBL4791244 | — | — | 1 | 6.30 |
| CHEMBL4776587 | — | — | 1 | 6.23 |
| CHEMBL4798895 | — | — | 1 | 6.23 |
| CHEMBL4790019 | — | — | 1 | 6.20 |
| CHEMBL4794470 | — | — | 1 | 5.90 |
| CHEMBL4794695 | — | — | 1 | 5.28 |
| CHEMBL4798591 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4795215 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4784348 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4786045 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4782713 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL522420 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL1823159 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL4786603 | — | IC50 | = | 22.7 | nM | 7.64 |
| CHEMBL4795928 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4795914 | — | IC50 | = | 413.0 | nM | 6.38 |
| CHEMBL4791244 | — | IC50 | = | 496.0 | nM | 6.30 |
| CHEMBL4776587 | — | IC50 | = | 591.0 | nM | 6.23 |
| CHEMBL4798895 | — | IC50 | = | 591.0 | nM | 6.23 |
| CHEMBL4790019 | — | IC50 | = | 635.0 | nM | 6.20 |
| CHEMBL4794470 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL4794695 | — | IC50 | = | 5225.0 | nM | 5.28 |
| CHEMBL4798591 | — | IC50 | = | 9670.0 | nM | 5.01 |