Assay Detail
Functional
CHEMBL4770224
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Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.70 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4795215 | — | — | 1 | 9.22 |
| CHEMBL4784348 | — | — | 1 | 8.68 |
| CHEMBL4782713 | — | — | 1 | 8.27 |
| CHEMBL4786045 | — | — | 1 | 8.25 |
| CHEMBL4786603 | — | — | 1 | 7.75 |
| CHEMBL4795928 | — | — | 1 | 7.20 |
| CHEMBL1823159 | — | — | 1 | 6.37 |
| CHEMBL4791244 | — | — | 1 | 6.32 |
| CHEMBL4795914 | — | — | 1 | 6.23 |
| CHEMBL4776587 | — | — | 1 | 6.17 |
| CHEMBL4790019 | — | — | 1 | 6.10 |
| CHEMBL522420 | — | — | 1 | 6.10 |
| CHEMBL4794470 | — | — | 1 | 6.04 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.51 |
| CHEMBL4798895 | — | — | 1 | 5.47 |
| CHEMBL4794695 | — | — | 1 | 5.19 |
| CHEMBL4798591 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4795215 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4784348 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4782713 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL4786045 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL4786603 | — | IC50 | = | 17.7 | nM | 7.75 |
| CHEMBL4795928 | — | IC50 | = | 62.9 | nM | 7.20 |
| CHEMBL1823159 | — | IC50 | = | 424.0 | nM | 6.37 |
| CHEMBL4791244 | — | IC50 | = | 477.0 | nM | 6.32 |
| CHEMBL4795914 | — | IC50 | = | 591.0 | nM | 6.23 |
| CHEMBL4776587 | — | IC50 | = | 682.0 | nM | 6.17 |
| CHEMBL4790019 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL522420 | — | IC50 | = | 787.0 | nM | 6.10 |
| CHEMBL4794470 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4798895 | — | IC50 | = | 3420.0 | nM | 5.47 |
| CHEMBL4794695 | — | IC50 | = | 6512.0 | nM | 5.19 |
| CHEMBL4798591 | — | IC50 | = | 8680.0 | nM | 5.06 |