Assay Detail
Functional
CHEMBL4770225
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Antiproliferative activity against human Daoy cells assessed as inhibition of cell growth
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Daoy |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.46 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4786045 | — | — | 1 | 9.52 |
| CHEMBL1823159 | — | — | 1 | 9.49 |
| CHEMBL4795215 | — | — | 1 | 9.47 |
| CHEMBL4782713 | — | — | 1 | 8.60 |
| CHEMBL4786603 | — | — | 1 | 8.36 |
| CHEMBL522420 | — | — | 1 | 8.30 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.91 |
| CHEMBL4795928 | — | — | 1 | 7.44 |
| CHEMBL4791244 | — | — | 1 | 6.46 |
| CHEMBL4795914 | — | — | 1 | 6.43 |
| CHEMBL4798895 | — | — | 1 | 6.37 |
| CHEMBL4790019 | — | — | 1 | 6.31 |
| CHEMBL4776587 | — | — | 1 | 6.07 |
| CHEMBL4794470 | — | — | 1 | 5.78 |
| CHEMBL4794695 | — | — | 1 | 5.40 |
| CHEMBL4798591 | — | — | 1 | - |
| CHEMBL4784348 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4786045 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1823159 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL4795215 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL4782713 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4786603 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL522420 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL4795928 | — | IC50 | = | 36.2 | nM | 7.44 |
| CHEMBL4791244 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL4795914 | — | IC50 | = | 371.0 | nM | 6.43 |
| CHEMBL4798895 | — | IC50 | = | 428.0 | nM | 6.37 |
| CHEMBL4790019 | — | IC50 | = | 494.0 | nM | 6.31 |
| CHEMBL4776587 | — | IC50 | = | 846.0 | nM | 6.07 |
| CHEMBL4794470 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL4794695 | — | IC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL4798591 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4784348 | — | IC50 | = | 0.005 | nM | - |