Assay Detail
Binding
CHEMBL4770232
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine brain tubulin polymerisation preincubated with compound followed by GTP addition and measured after 20 mins by turbidimetry based spectrophotometric method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.31 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4784348 | — | — | 1 | 6.43 |
| CHEMBL4795215 | — | — | 1 | 6.41 |
| CHEMBL4786045 | — | — | 1 | 6.32 |
| CHEMBL4795928 | — | — | 1 | 6.30 |
| CHEMBL4786603 | — | — | 1 | 6.29 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.27 |
| CHEMBL4782713 | — | — | 1 | 6.24 |
| CHEMBL1823159 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4784348 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4795215 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4786045 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4795928 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4786603 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4782713 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL1823159 | — | IC50 | = | 590.0 | nM | 6.23 |