Assay Detail
Binding
CHEMBL4770959
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human HDAC6 using Z-(Ac)Lys-AMC as substrate after 90 mins by fluorescence based micro plate assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.98 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4077645 | — | — | 1 | 8.22 |
| CHEMBL4649617 | — | — | 1 | 7.85 |
| CHEMBL4788940 | — | — | 1 | 6.82 |
| CHEMBL4789481 | — | — | 1 | 6.46 |
| CHEMBL3220922 | — | — | 1 | 6.38 |
| CHEMBL4789607 | — | — | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4077645 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4649617 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4788940 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL4789481 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL3220922 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4789607 | — | IC50 | = | 709.0 | nM | 6.15 |