Assay Detail
ADMET
CHEMBL4771176
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Displacement of [3H]-Raclopride from human D2 receptor (unknown origin) expressed in HEK293 cell membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Subcellular | Cell membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Antitubercular polyhalogenated phenothiazines and phenoselenazine with reduced binding to CNS receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.72 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL479 | THIORIDAZINE | 4.0 | 1 | 8.10 |
| CHEMBL4778666 | — | — | 1 | 6.43 |
| CHEMBL4797066 | — | — | 1 | 6.19 |
| CHEMBL4791959 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL479 | THIORIDAZINE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL4778666 | — | Ki | = | 367.0 | nM | 6.43 |
| CHEMBL4797066 | — | Ki | = | 639.0 | nM | 6.19 |
| CHEMBL4791959 | — | Ki | = | 688.0 | nM | 6.16 |